Veterinary-Grade Oral Care, Simplified
Learn the science behind our cutting-edge dental strips.
Key Independent Studies That Support Prodogi Strips
Peer-reviewed research validating the effectiveness of natural dental care for dogs.
Evaluation of anti-inflammatory and anti-nociceptive activities of the essential oil from Cordia verbenacea DC leaves
This study showed that the essential oil from Cordia verbenacea, rich in β-caryophyllene, exhibited strong anti-inflammatory and pain-reducing properties in animal models. These effects are highly relevant to oral care because inflammation and pain are central to periodontal disease. BCP's ability to downregulate pro-inflammatory cytokines suggests it may help reduce gum inflammation and protect tissues from damage caused by oral pathogens.
Read Full Study →Anti-Inflammatory and Analgesic Effects of β-Caryophyllene in Mouse Models of Inflammatory Pain
This study demonstrated that β-caryophyllene significantly reduced inflammation and pain. Since inflammation is the root cause of gingivitis and periodontal disease, BCP's potent anti-inflammatory action suggests it could help calm irritated gum tissue and potentially reduce periodontal pain—making it a promising compound for dental health products targeting inflammation at its source.
Read Full Study →The major volatile organic compound emitted from Arabidopsis thaliana flowers, the sesquiterpene (E)-β-caryophyllene, is a defense against a bacterial pathogen
This study found that β-caryophyllene acts as a natural antibacterial compound, helping plants defend against bacterial pathogens. The relevance to oral health is promising—suggesting BCP could serve a similar function in the mouth by targeting harmful bacteria that contribute to plaque and gum disease, all while being naturally derived and well-tolerated.
Read Full Study →β-Caryophyllene Reduces the Inflammatory Phenotype of Periodontal Cells by Targeting CB2 Receptors
This study demonstrates that β-caryophyllene (BCP), a natural CB2 receptor agonist, significantly reduces inflammation in human gingival fibroblasts and oral epithelial cells—key targets in oral mucositis and periodontitis. BCP inhibited pro-inflammatory markers (TNF-α, IL-1β, IL-6, IL-17A), boosted anti-inflammatory IL-13, and regulated transcription factors (NF-κB, STAT3, PPARγ), showing a dual anti-inflammatory mechanism.
Read Full Study →Spirulina maxima reduces inflammation and alveolar bone loss in Porphyromonas gingivalis induced periodontitis
In a model of periodontitis triggered by P. gingivalis, Spirulina maxima significantly decreased pro-inflammatory markers (TNF α, IL 1β, IL 6, NF κB), reduced enzyme activity (MPO, MMPs), and lowered alveolar bone loss. It also improved osteoblast markers via BMP 2/Smad pathways and restored the balance between osteoclasts and osteoblasts—highlighting Spirulina's potential as a protective agent for periodontal tissues.
Read Full Study →Clinical effects of subgingivally delivered Spirulina gel in chronic periodontitis cases: a placebo controlled clinical trial
In a clinical trial among chronic periodontitis patients, adding spirulina gel under the gums after scaling and root planing led to a greater reduction in pocket depth and improved attachment levels compared to scaling alone, demonstrating spirulina's local anti-inflammatory benefits and strong antioxidant effects.
Read Full Study →Green tea polyphenol epigallocatechin-3-gallate (EGCG) reduces periodontal breakdown in a periodontitis model
EGCG, the primary catechin in green tea, was shown to significantly reduce periodontal tissue destruction in animals with ligature-induced periodontitis. Its anti-inflammatory and antioxidative properties inhibited alveolar bone loss, suggesting a protective effect for periodontal health.
Read Full Study →Comparative evaluation of the antiplaque efficacy of green tea and chlorhexidine mouthwash: A randomized controlled clinical trial
In this clinical trial, green tea mouthwash showed significant antiplaque and anti-gingivitis efficacy comparable to chlorhexidine. Patients using green tea experienced reduced plaque index and gingival bleeding, supporting its use as a natural alternative to chemical antimicrobials.
Read Full Study →Bromelain: A potential strategy for the adjuvant treatment of periodontitis
This review outlines how bromelain—an enzyme mixture from pineapple—can attenuate periodontal disease through multiple mechanisms: reducing pathogenic bacteria, inhibiting neutrophil migration, down-regulating inflammatory mediators (e.g. IFN-γ, TNF-α, COX-2), and protecting alveolar bone. It's presented as a promising adjunct to standard periodontal therapy.
Read Full Study →Antimicrobial Efficacy of Irrigation with 4.8% Bromelain Extract against Porphyromonas gingivalis in the Periodontal Pockets: A Randomized Controlled Trial
In a randomized trial, irrigating periodontal pockets with 4.8% bromelain significantly reduced P. gingivalis counts compared to baseline—demonstrating clinically meaningful antimicrobial activity in vivo.
Read Full Study →Effects of Vitamin-B Complex Supplementation on Periodontal Wound Healing
In a randomized, placebo-controlled clinical trial, dogs with moderate to severe chronic periodontitis received vitamin B complex supplementation after periodontal flap surgery. After 90–180 days, the supplemented group showed better clinical attachment levels and reduced probing depths—suggesting B vitamins support periodontal wound healing post-surgery.
Read Full Study →To Evaluate the Effect of Vitamin B Complex on Wound Healing – A Clinical and Microbiological Study
In this split mouth clinical trial, 10 adults with periodontitis received vitamin B complex alongside flap debridement on impacted teeth. The treated sites displayed greater improvements in plaque index, gingival index, bleeding, pocket depth, and microbial load (including periodontal bacteria) than control sites—highlighting B vitamins' benefit for periodontal recovery.
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